OVERACTIVE AUTOPHAGY IS A PATHOLOGICAL MECHANISM UNDERLYING PREMATURE SUTURE OSSIFICATION IN NONSYNDROMIC CRANIOSYNOSTOSIS

Overactive autophagy is a pathological mechanism underlying premature suture ossification in nonsyndromic craniosynostosis

Abstract Nonsyndromic craniosynostosis (NSC) is the most common craniosynostosis with the primary defect being one or more fused sutures.In contrast to syndromic craniosynostosis, the etiopathogenesis of NSC is largely unknown.Here we show that autophagy, a major catabolic process required for the maintenance of bone homeostasis and bone growth, is

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NArchitecTURE: A Paradigm of Design with Nature

The relationship between architecture and nature has been a constant debate in the field.The preposition that architecture is an integral part of nature and even the natural landscape itself has accompanied the development of architectural theories over time.However, the question of how nature can be a design language intrinsically involved in the

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Construction of Two Box-Like Head-and-Face Shields by Japanese Origami Folding for Use During the COVID-19 Pandemic

Masaki Tago,1 Keizo Anzai,2 Yuichiro Sakamoto,3 Yohei Hamada,4 Shinichiro Ishikawa,5 Shinya Embroidery Hoops Kimura,6 Shu-ichi Yamashita1 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga, Japan; 3Department of Emergency and Critical Care Med

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